The rationales and inhibitor design principles will be discussed. STRUCTURE AND FUNCTIONS OF MNKS Mnk1 and Mnk2 are threonine /serine protein kinases and were originally discovered as the result of screening for substrate s or binding partners for Erk [56, 57]. pathway (Figure ?(Figure2).2). Erk1/2 and p38 then phosphorylate MAP kinase-interacting kinase 1 (Mnk1) and … Continue reading The rationales and inhibitor design principles will be discussed